Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy
نویسندگان
چکیده
منابع مشابه
Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy.
Chimeric antigen receptor (CAR) T cells have been highly successful in treating hematological malignancies, including acute and chronic lymphoblastic leukemia. However, treatment of solid tumors using CAR T cells has been largely unsuccessful to date, partly because of tumor-induced immunosuppressive mechanisms, including adenosine production. Previous studies have shown that adenosine generate...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2017
ISSN: 0021-9738,1558-8238
DOI: 10.1172/jci89455